Acetylsalicylic acid

Research use only, not for human use.

Aspirin (Acetylsalicylic acid) is a potent and selective inhibitor of cyclooxygenase (COX) with a broad range of pharmacological activities including anti-inflammation and pain relief.

Aspirin (Acetylsalicylic acid) is a potent and selective inhibitor of cyclooxygenase (COX) with a broad range of pharmacological activities including anti-inflammation and pain relief. Multiple studies have accumulated sufficient evidence to establish the association between the use of aspirin and a reduced risk of Ys including prostate Y, breast Y, colorectal Y, endometrial Y, and ovarian Y. Aspirin suppresses ovarian Y cells harboring COX-1 by acting as histone deacetylase inhibitors to up-regulate cell cycle arrest protein p21. Aspirin also inhibits the expression of COX-2 in human umbilical vein endothelial cells and neonatal rat ventricular cardiomyocytes resulting in reduced PG production and the down-regulation of ERK and NF-KB respectively.(In Vitro):Aspirin inhibits COX-1 and COX-2 in human articular chondrocytes, with IC50 values of 3.57 μM and 29.3 μM, respectively.Aspirin acetylates serine-530 of COX-1, thereby blocking thromboxane A synthesis in platelets and reducing platelet aggregation.Aspirin inhibits COX-2 protein expression through interference with binding of CCAAT/enhancer binding protein beta (C/EBPbeta) to its cognate site on COX-2 promoter/enhancer.Aspirin inhibits NF-κB-dependent transcription from the lgκ enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells.Aspirin induces apoptosis by the activation of caspases, the activation of p38 MAP kinase, release of mitochondrial cytochrome c, and activation of the ceramide pathway.(In Vivo):Aspirin (5-150 mg/kg, PO, once) shows significant antipyretic activity in adult yeast-fevered male rats.

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Animal Model:Male albino Charles River rats (200-250 g, 8 animals/group, fever was induced by 20 ml/kg of a 20 % aqueous suspension of brewer’s yeast which was injected SC in the back below the nape of the neck)Dosage:5, 25, 50, 100 and 150 mg/kg Administration:PO, once Result:Produced a statistically significant decrease of 0.23 ℃ at 15 min post-drug at the dose of 150 mg/kg. Antipyretic effect gradually increased in magnitude until a peak effect of 1.96 ℃ was reached at 120 min post-drug. The ED50 of aspirin was found to be 10.3 mg/kg with confidence limits of 1.8-23.0 mg/kg. The antipyretic response to aspirin is dependent on the dose of the compound administered.

Acetylsalicylic Acid

Chromatin/Epigenetic

COX

COX-1| COX-2

Inflammation/Immunology

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50-78-2

180.16

C9H8O4

>98% (HPLC)

Ethanol: 36 mg/mL (199.82 mM); DMSO: 36 mg/mL (199.82 mM)

O=C(O)C1=CC=CC=C1OC(C)=O

Benzoic acid, 2-(acetyloxy)-

(-20℃)

With Ice Pack

≥ 2 years